Antiplasmodial activity of the ethanol extract of Dacryodes edulis leaf in Plasmodium berghei infected mice

Background: Malaria treatment in Africa is increasingly becoming difficult resulting from Plasmodium falciparum resistant to available antimalarial agents. Therefore, evaluating plants used traditional medicines can lead alternative against malaria.Methods: This study evaluated the antiplasmodial activity of ethanol extract Dacryodes edulis chloroquine sensitive berghei NK65 strain mice. The 4-day suppressive test, repository and curative effect established rodent malaria infection models were assayed this study. oral acute toxicity test phytochemical screening also carried out on leaf extract.Results: (D. edulis) at varying doses 100 mg/kg, 200 400 mg/kg significantly (p<0.05) exhibited dose-dependent decrease parasitaemia suppressive, studies. Chloroquine 10 decreased levels three infections. comparable with standard drug. was found be non-toxic acutely mice.Conclusions: findings show that D. demonstrated high a fashion. Thus, supporting claims plant therapeutic importance for treatment, developed as an therapy disease.